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KMID : 0604520220480020135
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 2 p.135 ~ p.146
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Improvement of Antifungal Activity of for Water-Dispersed Cosmetic Formulations
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Lee Ye-Ji
Seo Jae-Yong
Yang Hyeon-Gap
Lee Ju-kyeong
Baek Sol-Bee
Cho Hyun-Dae
Jeong Noh-Hee
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Abstract
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In order to prevent microbial contamination and safely use cosmetics, it is essential to possess preservative power.
In this study, the antifungal effect was confirmed by improving the preservative system of the aqueous dispersion formulation, which has a weak preservative power against fungi, and various preservative systems were established to strengthen the preservative power against fungi. Five kinds of raw materials (sodium anisate, p-anisic acid, caprylhydroxamic acid, o-cymen-5-ol, hydroxyacetophenone) that have a benzene ring structure having a hydroxyl group and exist as protonated form in cosmetic formulations expected to improve antifungal activity in cosmetics were selected, and the minimum growth inhibitory concentration of the raw materials was determined through MIC assay. It was confirmed that the preservative power against mold was improved through the preservative efficacy test of 4 types of water dispersion formulations (cream, lotion, toner, and sun cream) in which 4 types of raw materials showing antimicrobial activity against mold were added to the preservative system. When p-anisic acid was used, it was confirmed that the preservative activity against mold was strengthened without the effect of inhibiting the preservative power against bacteria and yeast in all four formulations.
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KEYWORD
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cosmetics, preservative, microbial, antifungal, p-anisic acid
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